En
  • دکتری (1391)

    زیست شناسی - ژنتیک مولکولی

    دانشگاه تربیت مدرس،

  • کارشناسی (1384)

    زیست شناسی

    دانشگاه گیلان، رشت، ایران

  • مطالعه نقش اگزوزومهای مشتق از سلولهای بنیادی در تنظیم میکرو محیط توموری
  • بررسی نقش RNA های تنظیمی در مسیرهای سیگنالینگ سلول های توموری/ لوکمیایی
  • بررسی اثر هم افزایی داروهای شیمی درمانی و رویکرد های تعدیل بیان RNAهای تنظیمی در درمان سرطان
  • بررسی بیان ژن های شناسایی شده با رویکرد NGS در بدخیمی های انسانی
  • پزشکی مولکولی

دکتر صادق باباشاه دانشیار و عضو هیات علمی گروه ژنتیک دانشگاه تربیت مدرس و معاون پژوهشی مرکز تحقیقات توسعه زیست فناوری دانشگاه تربیت مدرس می باشند. ایشان مدرک دکتری تخصصی را در رشته ژنتیک مولکولی در سال 1391 از دانشگاه تربیت مدرس اخذ کرده اند. زمینه های تحقیقاتی مورد علاقه ایشان: • مطالعه نقش اگزوزوم های مشتق از سلولهای بنیادی در تنظیم میکرو محیط توموری • بررسی نقش RNA های تنظیمی در مسیرهای سیگنالینگ سلول های توموری لوکمیایی بررسی اثر هم افزایی داروهای شیمی درمانی و رویکرد های تعدیل بیان RNAهای تنظیمی در درمان سرطان • تغییرات بیانی Noncoding RNAs در روند تمایز عصبی سلول های بنیادی می باشد.

ارتباط

رزومه

The oncogenic and tumor suppressive roles of RNA‐binding proteins in human cancers

Amirreza Bitaraf, Ehsan Razmara, Babak Bakhshinejad, Hassan Yousefi, Mousa Vatanmakanian, Masoud Garshasbi, William C Cho, Sadegh Babashah
Journal Papers , 2021 February 8, {Pages }

Abstract

Posttranscriptional regulation is a mechanism for the cells to control gene regulation at the RNA level. In this process, RNA‐binding proteins (RBPs) play central roles and orchestrate the function of RNA molecules in multiple steps. Accumulating evidence has shown that the aberrant regulation of RBPs makes ?contributions?to the initiation and progression of tumorigenesis via numerous mechanisms such as genetic changes, epigenetic alterations, and noncoding RNA‐mediated regulations. In this article, we review the effects caused by RBPs and their functional diversity in the malignant transformation of cancer cells that occurs through the involvement of these proteins in various stages of RNA regulation including alternative splicing, st

Anatomical Studies of Genetic Variation Instabilities in Various Cancer

Mohammad Ghazimoradi, Shirin Farivar, Ehsan Zolghadr, Samaneh Montazeri, Toktam Tavabe Ghavami, Maryam Daryani, Sadegh Babashah
Journal Papers , 2021 January 28, {Pages }

Abstract

Background: Genome instability is one of the signi cant markers of cancers. This features is one of the most fundamental mechanism regarding cancer cells evolution. This major mechanism has been found mostly in some of cancer types and in less extends in other types. Majority of this instability occur mostly in chromosome scale or satellites.Results: In this regards whole exome data has been downloaded from Array express (EMBL-EBI). We investigate the amount of instability of genetic variations such as SNP, MNP and other types in various cancers. We also investigates this change in genome, chromosome and gene scale point of view in various type of cancers. Our ndings might enlighten some preservative mechanism in genome scale.Conclusion: Al

SMAD4 expression in renal cell carcinomas correlates with a stem-cell phenotype and poor clinical outcomes

Arezoo Rasti, Zahra Madjd, Leili Saeednejad Zanjani, Sadegh Babashah
Journal PapersFrontiers in Oncology , Volume 11 , 2021 January , {Pages 1114 }

Abstract

Renal cell carcinoma (RCC) is the most lethal neoplasm of common urologic cancers with poor prognoses. SMAD4 has a principal role in TGF-β (Transformis growth factorβ)-induced epithelial to mesenchymal transition (EMT) as a key factor in gaining cancer stem cell (CSC) features and tumor aggressiveness. This study aimed to evaluate the expression patterns and clinical significance of SMAD4 in RCC and the impact of its targeting on stem cell/ mesenchymal cells and EMT characteristics in renal spheroid derived cells (SDCs) compared to parental cells (PCs) in RCC. The expression pattern and clinical significance of SMAD4 was evaluated in RCC. SDCs were enriched using a sphere culture system. Then SDCs and their PCs were compared with respect

Identification of dysregulated competing endogenous RNA networks in glioblastoma: A way toward improved therapeutic opportunities

Saghar Rahnama, Babak Bakhshinejad, Farnoosh Farzam, Amirreza Bitaraf, Mohammad Hossein Ghazimoradi, Sadegh Babashah
Journal Papers , Volume 277 , 2021 July 15, {Pages 119488 }

Abstract

Glioblastoma is recognized as one of the leading causes of death worldwide. Although there have been considerable advancements in understanding the causative molecular mechanisms of this malignancy, effective therapeutic strategies are still in limited use. It has been revealed that non-coding RNAs (ncRNAs) play critical roles in glioblastoma development, while interactions between the regulatory molecules such as long ncRNAs (lncRNAs), microRNAs (miRNAs), transcribed pseudogenes, and circular RNAs (circRNAs) remain to be fully deciphered. Over the recent years, researchers have discovered a new category of RNA molecules called competing endogenous RNA (ceRNA). This kind of RNA can contribute to molecular interactions in the form of ceRNA n

SMAD4 Expression in Renal Cell Carcinomas Correlates With a Stem-Cell Phenotype and Poor Clinical Outcomes. Front

A Rasti, Z Madjd, L Saeednejad Zanjani, S Babashah, M Abolhasani, M Asgari, M Mehrazma
Journal PapersOncol , Volume 11 , 2021 May 3, {Pages 581172 }

Abstract

Renal cell carcinoma (RCC) is the most lethal neoplasm of common urologic cancers with poor prognoses. SMAD4 has a principal role in TGF-β (Transformis growth factorβ)-induced epithelial to mesenchymal transition (EMT) as a key factor in gaining cancer stem cell (CSC) features and tumor aggressiveness. This study aimed to evaluate the expression patterns and clinical significance of SMAD4 in RCC and the impact of its targeting on stem cell/mesenchymal cells and EMT characteristics in renal spheroid derived cells (SDCs) compared to parental cells (PCs) in RCC. The expression pattern and clinical significance of SMAD4 was evaluated in RCC. SDCs were enriched using a sphere culture system. Then SDCs and their PCs were compared with respect t

Up-regulation of miR-155 potentiates CD34+ CML stem/progenitor cells to escape from the growth-inhibitory effects of TGF-?1 and BMP signaling

Touba Mahdloo, Pantea Sahami, Reihaneh Ramezani, Mojtaba Jafarinia, Hamedreza Goudarzi, Sadegh Babashah
Journal PapersEXCLI journal , Volume 20 , 2021 January , {Pages 748 }

Abstract

microRNAs (miRNAs or miRs) play key roles in different stages of chronic myeloid leukemia (CML) pathogenesis. The present study aimed to demonstrate whether miR-155 enables CD34+ CML cells to escape from the growth-inhibitory effects of TGF-β1 and bone morphogenetic protein (BMP) signaling. Among differentially expressed miRNAs in CD34+ CML cells, miR-155 was highly up-regulated. QRT-PCR revealed an inverse correlation between miR-155 and two key members of the TGF-β pathway-TGF-βR2 and SMAD5. Results showed that SMAD5 is not only up-regulated through BMPs treatment, but recombinant TGF-β1 can also induce SMAD5 in CML cells. We also demonstrated that TGF-β1-mediated phosphorylation of SMAD1/5 was abolished by pre-treatment with the blo

Colorectal cancer cell-derived extracellular vesicles transfer miR-221-3p to promote endothelial cell angiogenesis via targeting suppressor of cytokine signaling 3

M Dokhanchi, K Pakravan, S Zareian, BM Hussen, M Farid, E Razmara, ...
Journal Papers , , {Pages }

Abstract

Circulating serum miR-1246 and miR-1229 as diagnostic biomarkers in colorectal carcinoma

R Rafiee, E Razmara, M Motavaf, M Mossahebi-Mohammadi, ...
Journal Papers , , {Pages }

Abstract

Identification of a six‐microRNA signature as a potential diagnostic biomarker in breast cancer tissues

M Mahmoudian, E Razmara, B Mahmud Hussen, M Simiyari, N Lotfizadeh, ...
Journal Papers , , {Pages }

Abstract

Assessment of the expression of long noncoding RNA RMST following induction of neuronal differentiation of NT2 pluripotent embryonic carcinoma cells

N Abbasi, H Fahimi, SH Jamaleddini, R Ramezani, S Babashah
Journal Papers , , {Pages }

Abstract

Functions of the SNAI family in chondrocyte‐to‐osteocyte development

E Razmara, A Bitaraf, B Karimi, S Babashah
Journal Papers , , {Pages }

Abstract

Whole-Transcriptome Analysis by RNA Sequencing for Genetic Diagnosis of Mendelian Skin Disorders in the Context of Consanguinity

L Youssefian, AH Saeidian, F Palizban, A Bagherieh, F Abdollahimajd, ...
Journal Papers , , {Pages }

Abstract

Evauation effects of silymarin on cytotoxicity and apoptosis on SW480 colon cancer cell line

Z Kamrani, M Heshmati, S Babashah
Journal Papers , , {Pages }

Abstract

Use of cellular exosomes as a new carrier in breast cancer gene therapy.

N Maleki, S Mirhakimi, S Babashah, A Sayadi, G Parnian, M Hadizadeh
Journal Papers , , {Pages }

Abstract

Analysis, quantification, and visualization of RT-LAMP technique for detection of COVID-19

MH Ghazimoradi, M Daryani, M Gharshasbi, E Zolghadr, A Khalafizadeh, ...
Journal Papers , , {Pages }

Abstract

UP-REGULATION OF MIR-155 POTENTIATES CD34 (+) CML STEM/PROGENITOR CELLS TO ESCAPE FROM THE GROWTH-INHIBITORY EFFECTS OF TGF-B1 AND BMP SIGNALING

T Mandloo, P Sahami, R Ramezani, M Jafarinia, H Goudarzi, S Babashah
Journal Papers , , {Pages }

Abstract

Up-regulation of miR-155 potentiates CD34+ CML stem/progenitor cells to escape from the growth-inhibitory effects of TGF-ß1 and BMP signaling

T Mahdloo, P Sahami, R Ramezani, M Jafarinia, H Goudarzi, S Babashah
Journal Papers , , {Pages }

Abstract

microRNA-141-3p-containing small extracellular vesicles derived from epithelial ovarian cancer cells promote endothelial cell angiogenesis through activating the JAK/STAT3 and

Sajjad Masoumi-Dehghi, Sadegh Babashah, Majid Sadeghizadeh
Journal PapersJournal of Cell Communication and Signaling , 2020 February 7, {Pages 12-Jan }

Abstract

Paracrine signaling between tumor and surrounding stromal cells is critical for the maintenance of tumor microenvironment during ovarian cancer progression. Small extracellular vesicles (sEVs; exosomes in particular) are nano-sized vesicles secreted actively by many cells including tumor cells and are found to have fundamental roles in intercellular communication through shuttling functional RNAs. Although microRNAs (also called miRNAs or miRs), small non-coding RNAs regulating gene expression, are selectively accumulated in tumor sEVs and can mediate intercellular communication, the exact biological mechanisms underlying the functions of exosomal miRNAs in ovarian tumor angiogenesis remain unclear. In this study, sEVs were isolated from co

10th Royan Institute's International Summer School on" Molecular Biomedicine: From Diagnostics to Therapeutics".

Sharif Moradi, Parisa Torabi, Saeed Mohebbi, Sara Amjadian, Piter Bosma, Farnoush Faridbod, Vahid Khoddami, Morteza Hosseini, Sadegh Babashah, Maryam Ghotbaddini, Arezoo Rasti, Faezeh Shekari, Hamid Sadeghi-Abandansari, Jafar Kiani, Mehdi Shamsara, Mohamm
Journal PapersBioEssays: news and reviews in molecular, cellular and developmental biology , 2020 April 17, {Pages e2000042 }

Abstract

Author information: (1)Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, 1665659911, Iran. (2)Department of Cancer Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Isar 11, Babol, 47138-18983, Iran. (3)Amsterdam UMC, University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Meibergdreef 69-71, 1105 BK, Amsterdam, The Netherlands. (4)School of Chemistry, College of Science, University of Tehran, Tehran, 1417614411, Iran. (5)Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehr

10th Royan Institute's International Summer School on “Molecular Biomedicine: From Diagnostics to Therapeutics”

Sharif Moradi, Parisa Torabi, Saeed Mohebbi, Sara Amjadian, Piter Bosma, Farnoush Faridbod, Vahid Khoddami, Morteza Hosseini, Sadegh Babashah, Maryam Ghotbaddini, Arezoo Rasti, Faezeh Shekari, Hamid Sadeghi‐Abandansari, Jafar Kiani, Mehdi Shamsara, Mohamm
Journal PapersBioEssays , Volume 42 , Issue 6, 2020 June , {Pages 2000042 }

Abstract

For the past nine years, Royan Institute (Tehran, Iran) has held annual international summer schools to educate and promote key basic and applied concepts regarding stem cells, cancer, personalized medicine, tissue engineering, and developmental biology. The last “Royan International Summer School” was focused on latest molecular approaches to disease therapy as well as early diagnosis of human diseases. The summer school, which hosted speakers from the Netherlands, US, and Iran as well as more than 250 researchers, was began on 13 July 2019 at Royan Institute and ended on 17 July 2019. The speakers discussed genome-editing technologies, gene-and RNA interference (RNAi) therapies, cancer vaccines, and molecular diagnosis via biomarkers

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دروس نیمسال جاری

  • كارشناسي ارشد
    ايمنو ژنتيك ( واحد)
    دانشکده علوم زیستی، گروه ژنتيك
  • كارشناسي ارشد
    بيو انفورماتيك ( واحد)
  • كارشناسي ارشد
    بيوانفورماتيك ( واحد)
  • كارشناسي ارشد
    تنظيم اپي ژنتيك سلولهاي بنيادي ( واحد)

دروس نیمسال قبل

  • دكتري
    مباحث جديد در ژنتيك (ويژه) ( واحد)
    دانشکده علوم زیستی، گروه ژنتيك
  • كارشناسي ارشد
    سلول هاي بنيادي و باز سازي بافت ( واحد)
  • 1398
    الموح, منصور
    اثر اگزوزوم‌هاي مشتق از سلول‌هاي بنيادي مزانشيمي تحت شرايط استرس اكسيداتيو بر تعديل بيان مسير JAK/STAT/VEGF در سلول‌هاي سرطاني پستان.
  • 1399
    شيخ بهائي, محبوبه
  • معاون پژوهشی و اجرایی مرکز تحقیقات توسعه زیست فناوری دانشگاه تربیت مدرس (1398 - 1401)
  • برگزیده پانزدهمین جشنواره جوان خوارزمی، پژوهش های بنیادی، آذر 1392
  • پژوهشگر جوان برجسته کشور در حیطه علوم پایه شاخه زیست شناسی، جایزه ابوریحان فرهنگستان علوم، 1400

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